Lipocalin Family

Lipocalin Family is a group of proteins with diverse functions, which are characterized by a conserved tertiary structure that can bind and transport small hydrophobic molecules. For example, retinol binding protein (RBP) specifically binds to retinol and is responsible for its transport in the bloodstream. Apolipoprotein D (ApoD) is involved in lipid metabolism and transport. Lactoferrin has antibacterial and iron-binding properties. Prostaglandin D (PGDS) is crucial in the synthesis of prostaglandin D2, which plays roles in various physiological and pathological processes. These lipocalin subtypes have different tissue distributions and functions, and are involved in many biological processes such as vision maintenance, immune defense, lipid metabolism and signal transduction^[1]^[2].

References:

[1]. Flower DR. The lipocalin protein family: structure and function. Biochem J. 1996 Aug 15;318 ( Pt 1)(Pt 1):1-14. [Content Brief]

[2]. Flower DR, et al. The lipocalin protein family: structural and sequence overview. Biochim Biophys Acta. 2000 Oct 18;1482(1-2):9-24. [Content Brief]

Lipocalin Family Related Products (9):

By Effects:	Ligand (1) Inhibitors (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-148364

ZINC00784494	Inhibitor	99.32%
ZINC00784494 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00784494 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00784494 has good potential for research in inflammatory breast cancer (IBC).

HY-143793

RBP4 inhibitor 1	Inhibitor	99.74%
RBP4 inhibitor 1 (compound 43b) is a potent and orally active retinol-binding protein 4 (RBP4) inhibitor with IC₅₀s of 28 nM and 110 nM for human and mouse RBP4. RBP4 inhibitor 1 has a potent and long-lasting blood RBP4-level-reducing effect in mice.

HY-P1924

IRBP(651-670) human, mouse		99.36%
Interphotoreceptor retinoid-binding protein(668-687), the amino acid residues 668 to 687 of human interphotoreceptor retinoid binding protein (IRBP), induces uveitis.

HY-164959

ZINC00230567	Inhibitor	99.69%
ZINC00230567 is an inhibitor for Lipocalin-2 (LCN2). ZINC00230567 reduces the colony formation and cell viability of cell SUM149, and exhibits anti-tumor efficacy.

HY-106580

Plafibride
Plafibride (ITA 104) is an orally active hypolipemic, platelet aggregation inhibitor.

HY-W339816

(S,R)-Bis(monomyristoylglycero)phosphate ammonium
(S,R)-Bis(monomyristoylglycero)phosphate ammonium actively contributes to cargo sorting by promoting the degradation and sorting of lipids, and it plays a critical role in the sorting of polyunsaturated fatty acids (PUFAs) within acidic organelles. This phospholipid features two phosphate-linked glycerol molecules arranged in a unique sn-1 glycerophospho-sn-1′ glycerol stereoconformation, with each glycerol molecule esterified to a myristic acid. Typically, it is found in the intraluminal vesicles (ILVs) of late endosomes and lysosomes.

HY-147366

RBP4 ligand-1	Inhibitor
RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4_SPA IC₅₀ and RBP4–TTR FRET IC₅₀ values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively.

HY-145629

Palsucibep pegol
Palsucibep pegol is a engineered human lipocalin-2 binding protein. Palsucibep pegol binds to hepcidin.

HY-139394

Arachidonoyl-1-thio-glycerol	Ligand
Arachidonoyl-1-thio-glycerol (Compound 5) is an nonretinoid ligand lipid that can interact with cellular retinol binding protein 2 (CRBP2).

Name
Email *

	Sorry, but the email address you supplied was invalid.